Seeking fertility treatment after 40 comes with unique challenges — but also real possibilities. In 2026, San Diego women over 40 are increasingly turning to specialists who understand advanced maternal age fertility, including the team at Hanabusa IVF, which specializes in personalized, low-stimulation IVF for complex cases.
Fertility Changes After 40
After age 40, egg quantity and quality decline more rapidly than at any other point in a woman’s reproductive life. AMH levels drop, the proportion of chromosomally abnormal eggs increases, and the chances of natural conception fall significantly. However, many women in their early-to-mid 40s still produce viable eggs and can achieve pregnancy with the right fertility support.
IVF Success Rates Over 40
IVF success rates using a woman’s own eggs decline with age, particularly after 42. Success rates vary significantly depending on the clinic and protocol used. Clinics that specialize in treating older patients and DOR patients — like Hanabusa IVF’s fertility over 40 program — often report outcomes that exceed national averages for this age group.
Treatment Approaches for Women Over 40
Mini IVF and natural cycle IVF are often preferred for women over 40 because they are gentler, less expensive, and may yield better egg quality than aggressive stimulation protocols. Preimplantation genetic testing (PGT) is frequently recommended to screen embryos for chromosomal abnormalities before transfer. Donor egg IVF is another option for women who wish to maximize their chances of a healthy pregnancy.
Preimplantation Genetic Testing (PGT)
PGT allows embryos to be tested for chromosomal abnormalities prior to transfer, significantly improving the chances of a successful, healthy pregnancy for women over 40. By transferring only euploid (chromosomally normal) embryos, clinicians can reduce miscarriage risk and improve live birth rates regardless of maternal age.
Taking the First Step
If you are over 40 and considering fertility treatment in San Diego, schedule a comprehensive fertility evaluation at Hanabusa IVF. This will include an AMH test, AFC ultrasound, and a consultation to discuss your individual options and realistic expectations.
Vilma Hahn is an Alaskan native who has been blogging about life in the most Northern state for over 10 years. As a freelance writer, Vilma has traveled extensively through Alaska, collecting stories and experiences to share on her blog. She shares stories about hiking and camping, visiting small towns, and outdoor adventures. Vilma loves to share her enthusiasm for life in Alaska and hopes to encourage people from all over the world to visit the 49th state.